Well this is very late but better late than never.
Yes, a big dog can impregnate a small female. Any intact male of any breed can impregnate any intact female of any breed as long as he is able to position himself to penetrate her and tie successfully.
However, the female will not be capable of carrying monster pups to full term so the end result will be the death of the female and the pups will not survive.
One of the cardinal rules of cross breeding is that the size of the mates should be at least equitable or the female is larger.
The smaller the female, the less likely she can safely carry the load.
This is why you don’t see male St. Bernard-female poodle mixes, for example (that’s a silly one but it’s just to illustrate the point).

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